Solid State NMR Spectroscopy for Biopolymers: Principles and Applications by: Hazime Saitô, Isao Ando, Akira Naito,

Solid State NMR Spectroscopy for Biopolymers: Principles and Applications by: Hazime Saitô, Isao Ando, Akira Naito

Publisher: Springer
Number Of Pages: 464
Publication Date: 2006-08-18
Sales Rank: 1731586
ISBN / ASIN: 1402043023
EAN: 9781402043024
Binding: Hardcover
Manufacturer: Springer
Studio: Springer
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Book Description:

When considering the biological significance and industrial and medical applications of biopolymers, it is crucial to know details of their secondary structure, dynamics and assembly. The biopolymers include globular, membrane and fibrous proteins, polypeptides, nucleic acids, polysaccharides and lipids. Solid state NMR spectroscopy has proved to be the most suitable and unrivaled means for investigations of biopolymers. The major advantage of solid state NMR spectroscopy is that the resulting line widths can be manipulated experimentally and are not influenced by motional fluctuation of proteins under consideration as a whole.

Solid State NMR Spectroscopy for Biopolymers: Principles and Applications provides a comprehensive account on how the conformation and dynamics of such biopolymers can be revealed by solid state NMR spectroscopy. Special efforts have been made towards the historical and chronological consequences of a variety of applications and the dynamic aspects of the biopolymer system. In particular, the authors emphasise how important it is to record the most simple DD-MAS (one pulse excitation with high power decoupling) as a mean of locating very flexible portions of membrane proteins and membrane associated peptides. The authors also demonstrate that dynamic features of membrane proteins with a timescale of fast (10⁸ Hz) and intermediate (10⁴ -10⁵ Hz) fluctuation motions can be revealed easily by specific suppression of peaks.
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